نتایج جستجو برای: Conformational Epitope

تعداد نتایج: 56057  

Journal: :iranian journal of immunology 0
fatemeh hajighasemi department of immunology, school of public health, tehran university of medical sciences soheila gharagozlou department of immunology, school of public health, tehran university of medical sciences nasrin moheghi department of immunology, school of public health, tehran university of medical sciences roya ghods monoclonal antibody research center, avesina research center, tehran, iran jalal khoshnoodi department of immunology, school of public health, tehran university of medical sciences fazel shokri department of immunology, school of public health, tehran university of medical sciences

background: there are two subclasses of human iga (iga1 and iga2) that differ in antigenic properties and in chemical composition. the constant domains of α1 and α2 heavy chains have >95% sequence homology though major structural differences exist in the hinge region. quantitation of iga subclass levels depends on the availability of monoclonal antibodies (mabs) specific for conserved conformat...

Journal: :journal of arthropod-borne diseases 0
naghmeh poorinmohammad department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, isfahan, iran. hassan mohabatkar department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, isfahan, iran.

background : the aim of this study was to generate in silico 3d-structure of the envelope protein of ahfv using homology modeling method to further predict its conformational epitopes and help other studies to investigate its structural features using the model. methods : a 3d-structure prediction was developed for the envelope protein of alkhumra haemorrhagic fever virus (ahfv), an emerging ti...

2011
M. R. Widyanto

Predicting of conformational epitope is one of the major challenge in the field of vaccine design. Several methods have been developed for predicting conformational epitope but that methods have mostly been based on protein sequence and not very effective. This is the first attempt in this are to predict conformational epitope using fuzzy inference system mamdani. The proposed method based on a...

Journal: :Endocrinology 2004
Takao Ando Rauf Latif Samira Daniel Katsumi Eguchi Terry F Davies

The TSH receptor (TSHR) is the primary antigen in Graves' disease. In this condition, autoantibodies to the TSHR that have intrinsic thyroid-stimulating activity develop. We studied the epitopes on the native TSHR using polyclonal antisera and monoclonal antibodies (mAbs) derived from an Armenian hamster model of Graves' disease. Of 14 hamster mAbs analyzed, five were shown to bind to conformat...

Fatemeh Hajighasemi Fazel Shokri, Jalal Khoshnoodi Nasrin Moheghi Roya Ghods Soheila Gharagozlou

Background: There are two subclasses of human IgA (IgA1 and IgA2) that differ in antigenic properties and in chemical composition. The constant domains of α1 and α2 heavy chains have >95% sequence homology though major structural differences exist in the hinge region. Quantitation of IgA subclass levels depends on the availability of monoclonal antibodies (MAbs) specific for conserved conformat...

2014
Anders Christiansen Christian Skjodt Hansen Jens Vindahl Kringelum Ole Lund Katrine Lindholm Bogh Martin Dufva

Background Characterization of allergen epitopes is an essential task in unraveling the molecular mechanisms of allergy. At present, the procedures to characterize conformational epitopes are relatively laborious and, consequently, knowledge of conformational allergen epitopes is limited. The aim of this study was to couple an established epitope mapping approach, based on phage-displayed pepti...

Journal: :Journal of virology 2011
Mattia Bonsignori Kwan-Ki Hwang Xi Chen Chun-Yen Tsao Lynn Morris Elin Gray Dawn J Marshall John A Crump Saidi H Kapiga Noel E Sam Faruk Sinangil Marie Pancera Yang Yongping Baoshan Zhang Jiang Zhu Peter D Kwong Sijy O'Dell John R Mascola Lan Wu Gary J Nabel Sanjay Phogat Michael S Seaman John F Whitesides M Anthony Moody Garnett Kelsoe Xinzhen Yang Joseph Sodroski George M Shaw David C Montefiori Thomas B Kepler Georgia D Tomaras S Munir Alam Hua-Xin Liao Barton F Haynes

V2/V3 conformational epitope antibodies that broadly neutralize HIV-1 (PG9 and PG16) have been recently described. Since an elicitation of previously known broadly neutralizing antibodies has proven elusive, the induction of antibodies with such specificity is an important goal for HIV-1 vaccine development. A critical question is which immunogens and vaccine formulations might be used to trigg...

Journal: :Molecular immunology 2010
Jason M Robotham Lixin Xia LeAnna N Willison Suzanne S Teuber Shridhar K Sathe Kenneth H Roux

Both linear and conformational epitopes likely contribute to the allergenicity of tree nut allergens, yet, due largely to technical issues, few conformational epitopes have been characterized. Using the well studied recombinant cashew allergen, Ana o 2, an 11S globulin or legumin, we identified a murine monoclonal antibody which recognizes a conformational epitope and competes with patient IgE ...

Background: Immunoglobulins are a group of proteins that have important role in defense against microorganisms. Immunoglobulins consist of heavy and light chains. In human, immunoglobulin light chain comprises of two isotypes: Kappa (K) and lambda (λ) based on amino acid differences in carboxylic end of their constant region. Marked changes in the K to λ ratio can happen in monocl...

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